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Summary
The pharmacokinetics of enrofloxacin was investigated in 10-day-old broiler chicks. Enrofloxacin was orally administered at a dose of 10 mg /kg body weight daily for 5 days. Blood samples were taken for 5 days prior to and after 0.25, 0.5, 1, 2, 4, 8, 12, and 24 hrs following, drug administration. Using microbiological agar gel diffusion analysis, plasma concentration of the enrofloxacin and its metabolites were determined by correlating the composite of antimicrobial activity of enrofloxacin and its metabolites with the actual concentration. After drug administration, the plasma concentration- time curve was characterized by two compartment open model. The elimination half-life and the mean residence time of enrofloxacin for plasma were 2.06 and 33.91 hrs, respectively. Enrofloxacin was absorbed slowly with time to reach its maximal plasma concentration of 3.91 mg/l after 1.5 hr. Enrofloxacin presented an extensive AUC indicating that the drug remains longer than other quinolones in the body. The study concluded that a dose of 10 mg/kg given orally at 24 h interval for five successive days to broiler chicks is suitable for control of bacterial infection in broiler chicks.  


 

 
 
   
 
 

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