Triclabendazole and Oxyclozanide were tested for the treatment of cattle naturally infected with F. gigantica. Nine calves naturally infected with F. gigantica, aged between two to three-year old were used. They were divided into three groups, three animals each; group one was treated with Triclabendazole at dose of 12 mg/kg, group two treated with Oxyclozanide at dose of 12 mg/kg and the third group was left untreated as a control group. At weekly intervals, haemoglobin concentration and PCV were measured, and faecal samples were collected for egg count per gram of faeces. The animals were slaughtered 8 weeks after treatment and the efficacy of the drugs was assessed according to worm burden reduction. The reduction of worm in the Triclabendazole-treated group was 100%, while in the Oxyclozanide-treated group was 80%.