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Summary The current study was designed to evaluate the efficacy of oxyclozanide against F. gigantica in experimentally infected desert sheep in the Sudan. Nine desert male lambs weighting 18-24 kg were divided randomly into three groups (each of 3 lambs). Each lamb was inoculated orally with 400 metacercariae of F. gigantica obtained from laboratory colonies of Lemnia natalensis infected with miracidia of bovine origin obtained from Alsahafa abattoir. Group 1was drenched with triple dose of oxyclosanide (1mg/1 Kg B.W) 4 weeks post infection. Lambs in group 2 received the dose recommended by the manufacturer (1mg/3kg B.W) 8 weeks post infection, whereas, group 3 lambs were kept as infected untreated controls. The lambs were slaughtered and the average number of worms recovered was 26, 10 and 74, respectively. The number of worms recovered was significantly different (p 0.05). The efficacy of oxyclozanide was 64.57% and 86.16% in group 1and 2, respectively. It seems that Oxyclozanide is more effective against 8 than 4- week-old F. gigantica infection in desert sheep in Sudan. Neither significant difference (p 0.05) in worm size nor clinical side effects were observed in all experimental groups.

 
 
   
 
 

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