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Summary
The current study was designed to evaluate the efficacy of oxyclozanide against F. gigantica
in experimentally infected desert sheep in the Sudan. Nine desert male lambs weighting 18-24 kg
were divided randomly into three groups (each of 3 lambs). Each lamb was inoculated orally with
400 metacercariae of F. gigantica obtained from laboratory colonies of Lemnia natalensis infected
with miracidia of bovine origin obtained from Alsahafa abattoir. Group 1was drenched with triple
dose of oxyclosanide (1mg/1 Kg B.W) 4 weeks post infection. Lambs in group 2 received the dose
recommended by the manufacturer (1mg/3kg B.W) 8 weeks post infection, whereas, group 3 lambs
were kept as infected untreated controls. The lambs were slaughtered and the average number of
worms recovered was 26, 10 and 74, respectively. The number of worms recovered was significantly
different (p 0.05). The efficacy of oxyclozanide was 64.57% and 86.16% in group 1and 2,
respectively. It seems that Oxyclozanide is more effective against 8 than 4- week-old F. gigantica
infection in desert sheep in Sudan. Neither significant difference (p 0.05) in worm size nor clinical
side effects were observed in all experimental groups.
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