The study was conducted on Nubian goats of 6 to 9 month-old and of both sexes.
Dried leaves powder of Guiera senegalensis was mixed with water and drenched to the
animals at a dose of 1 or 2 gm/kg/day for 126 days.
Chronic toxicity was evidenced by clinical signs pathological and biochemical
changes. The main signs were watery diarrhoea, inappetance, dullness, weakness of the
hind limbs and respiratory distress. Later, these signs disappeared and the animals
appeared healthy. The most evident pathological findings were hydrothorax,
hydropretonium, hydropericardium and enlarged liver. Histopathological changes were
congestion, degeneration and necrosis of the liver, kidneys and intestinal villi which
showed intense infiltration of inflammatory cells and pancreatic hyperplasia. These
changes were correlated with the activity of asparate amino transferase (AST) and
alkaline phosphatase (ALP) the concentration of cholesterol, sodium and potassium in
the serum, and with the haematological values. The effect of the plant on male was less
marked than female goats. However, there was a gradual increase in mean body-weight
of both sexes. One female and one male goat that received the plant at a dose of
1g/kg/day, died on day 6 and 42, respectively.