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Summary The study was conducted on Nubian goats of 6 to 9 month-old and of both sexes. Dried leaves powder of Guiera senegalensis was mixed with water and drenched to the animals at a dose of 1 or 2 gm/kg/day for 126 days. Chronic toxicity was evidenced by clinical signs pathological and biochemical changes. The main signs were watery diarrhoea, inappetance, dullness, weakness of the hind limbs and respiratory distress. Later, these signs disappeared and the animals appeared healthy. The most evident pathological findings were hydrothorax, hydropretonium, hydropericardium and enlarged liver. Histopathological changes were congestion, degeneration and necrosis of the liver, kidneys and intestinal villi which showed intense infiltration of inflammatory cells and pancreatic hyperplasia. These changes were correlated with the activity of asparate amino transferase (AST) and alkaline phosphatase (ALP) the concentration of cholesterol, sodium and potassium in the serum, and with the haematological values. The effect of the plant on male was less marked than female goats. However, there was a gradual increase in mean body-weight of both sexes. One female and one male goat that received the plant at a dose of 1g/kg/day, died on day 6 and 42, respectively.

 
 
   
 
 

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