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ãáÎÕ ÇáÈÍË áÚÞÇÑ ÇáÓÇãæÑíä. ÅÓÊÎÏãÊ Ýí ªÐå ÇáÊÌÑÈÉ ÃËäÇä (Trypanosoma vivax) ÊãÊ ÏÑÇÓÉ ÍÓÇÓíÉ ØÝíáì ÇáãËÞÈíÉ ÇáäÔØÉ æ ËáÇËæä ÑÃÓÇ ãä ÇáãÇÚÒ ÇáäæÈí ÍíË Êã ÊÞÓíã ÇáãÇÚÒ Çáì ÓÈÚÉ ãÌãæÚÇÊ æ ÊãÊ ÚÏæí ÇáÓÊÉ ãÌãæÚÇÊ ÇáÃæáì ÈËáÇË ÓáÇáÇÊ ãÎÊáÝÉ (ÓáÇáÉ áßá ãÌãæÚÊíä) ãä ØÝíáì ÇáãËÞÈíÉ ÇáäÔØÉ æ ªì ÍáÝÇ , ßäÇäÉ æ ÓäÇÑ. ÊãÊ ÇáÚÏæì ÈÇáÍÞä ÚÈÑ ÇáæÑíÏ ÇáæÏÇÌí . Êã ÍÞä ËáÇËÉ ãä ÇáãÌãæÚÇÊ ÇáãÕÇÈÉ (ßá ãÌãæÚÉ ãÕÇÈÉ ÈÓáÇáÉ ãÎÊáÝÉ) ÈÏæÇÁ ÇáÓÇãæÑíä ÈÌÑÚÉ 0.5 ãáÌã/ßáÌã ãä ÇáæÒä ÇáÍì; ÈíäãÇ ÙáÊ ÇáãÌãæÚÉ ÇáÓÇÈÚÉ ÈÏæä ÚÏæì ßãÌãæÚÉ ÖÇÈØÉ . Êã ÇÓÊÚãÇá ÚÏÉ ØÑÞ áÊÔÎíÕ ÇáãÑÖ ÔãáÊ ØÑíÞÉ ÊÑßíÒ ÇáÏã Ýí ÇáÃäÇÈíÈ ÇáÔÚÑíÉ ÈæÇÓØÉ ÇáØÑÏ ÇáãÑßÒí æ ØÑíÞÉ ÝÍÕ ÇáÛÔÇÁ ÇáÃÈíÖ ÈÇÓÊÎÏÇã ãÌªÑ Ðæ ÎáÝíÉ ãÚÊãÉ. ÃËÈÊÊ ÇáÏÑÇÓÉ Ãä ááãÇÚÒ ÇáäæÈí ÞÇÈáíÉ ÚÇáíÉ ááÅÕÇÈÉ ÈØÝíáì ÇáãËÞÈíÉ ÇáäÔØÉ ÍíË ÃÙªÑÊ ÇáÍíæÇäÇÊ ÇáãÕÇÈÉ ÃÚÑÇÖ Çð ãÊäæÚÉ æ Þíã ãÎÊáÝÉ Ýí ÇáÏã .ßÐáß ÃÏÊ ÇáÅÕÇÈÉ Åáì äÝæÞ ÈÚÖ ÍíæÇäÇÊ ÇáÊÌÑÈÉ . ÃÏÊ ÇáÅÕÇÈÉ Åáì ÅäÎÝÇÖ ãÚäæí Ýí äÓÈÉ ÍÌã ÇáÎáÇíÇ ÇáãÊßÏÓÉ¡ÇáÚÏÏ Çáßáí áßÑíÇÊ ÇáÏã ÇáÍãÑÇÁ æ ÊÑßíÒ ÇáÎÖÇÈ æ ÇáÚÏÏ Çáßáí áßÑíÇÊ ÇáÏã ÇáÈíÖÇÁ Ýì ÇáÍíæÇäÇÊ ÇáãÕÇÈÉ ãÞÇÑäÉ ÈÇáÊì Êã ÚáÇÌªÇ æ ÛíÑ ÇáãÕÇÈÉ . ÝÞØ ãÇÚÒ æÇÍÏ ãä ãÌãæÚÉ ÓäÇÑ áã íÓÊÌíÈ ááÚáÇÌ ÈÇáÓÇãæÑíä ããÇ íÏá Úáì ÝÚÇáíÉ ÇáÓÇãæÑíä áÚáÇÌ ØÝíá ÇáãËÞÈíÉÇáäÔØÉ. Summary This study was carried out to investigate the sensitivity of Trypanosoma vivax to isometamidium chloride. In this study, three T. vivax stocks were used to infect Nubian goats; these were Halfa, Kenana and Sennar stocks. Thirty-two Nubian goats were used for the experiment. They were divided into seven groups; six were experimentally infected with three stocks of T. vivax, two groups with each stock, through the jugular vein. Then three of these infected animal groups, one from each stock-infected groups, were treated with isometamidium chloride at a dose of 0.5 mg/Kg live b.wt, while the seventh group served as uninfected control group. The haematocrit centrifugation technique (HCT) and dark-ground phase-contrast buffy coat technique (BCT) were used for detecting trypanosome infection. The study showed that Nubian goats were highly susceptible to T. vivax infection. Infected animals showed variable clinical signs and different values in haematological parameters. Also the infection led to death of five of the infected animals. The infection resulted in a significant increase (P≤ 0.05) in body temperature and significant decrease (P≤ 0.05) in packed cell volume (PCV), total red blood cells counts (RBCs), haemoglobin concentration (Hb) values and white blood cells counts (WBCs) in all infected animals compared to the treated and uninfected control groups. Relapse was detected after treatment with isometamidium chloride at 0.5 mg/kg bwt in only one animal of treated Sennar isolate-infected group. This suggested that Isometamidium is effective in treatment of T. vivax.

 
 
   
 
 

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